diff --git a/src/config.rs b/src/config.rs
index b1d5de2..8a94a2d 100644
--- a/src/config.rs
+++ b/src/config.rs
@@ -273,6 +273,9 @@ pub struct GeneralConfig {
     #[serde(default = "def_false")]
     pub focus_follows_mouse_mode: bool,
 
+    #[serde(default = "def_false")]
+    pub left_handed_mouse: bool,
+
     #[serde(default = "def_false")]
     pub block_game_input: bool,
 
diff --git a/src/overlays/screen.rs b/src/overlays/screen.rs
index b76b171..f576f63 100644
--- a/src/overlays/screen.rs
+++ b/src/overlays/screen.rs
@@ -134,6 +134,17 @@ impl InteractionHandler for ScreenInteractionHandler {
             _ => MOUSE_LEFT,
         };
 
+        // Swap left and right buttons if left-handed mode is enabled
+        let btn = if app.session.config.left_handed_mouse {
+            match btn {
+                MOUSE_LEFT => MOUSE_RIGHT,
+                MOUSE_RIGHT => MOUSE_LEFT,
+                other => other,
+            }
+        } else {
+            btn
+        };
+
         if pressed {
             set_next_move(u64::from(app.session.config.click_freeze_time_ms));
         }